3-FPM

15.00110.00

3-FPM acts as a norepinephrine-dopamine releasing agent with EC50 values of 43 nM and 30 nM, respectively.It shows only negligible efficacy as a releaser of serotonin, with an EC50 value of 2558 nM.

Evaluation of its metabolic pathway revealed N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation, and degradation of the ethyl‐bridge yielding the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations.

Clear